Aging

The buildup of defective tau proteins is a prominent feature of neurodegenerative diseases such as Alzheimer’s. The faulty proteins form tangles that disrupt brain function and kill nerve cells, or neurons. Experiments in human cell cultures reveal a mechanism through which scientists can regulate defective tau protein levels. Now, scientists have identified a molecule that
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Large-scale research suggests that drinking alcohol in older age may lower mortality risk. However, the scientists are cautious about potential biases in their own research and say that more research is necessary. Does moderate drinking in older age have any health benefits? A new study investigates. The debate around the potential health benefits of alcohol
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A recent study concludes that social interaction might be more than just a pleasant pastime; it might help doctors predict an individual’s risk of cognitive decline and, perhaps, dementia. How does social interaction influence cognitive decline? Cognitive decline refers to a general reduction in mental abilities over time. It affects many people as they age
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Researchers have designed a brain aging model to investigate the factors that contribute to cognitive decline, borrowing principles from precision medicine. How can we tackle cognitive decline? Cognitive decline affects a person’s ability to focus, remember, and make decisions. Its severity can range from mild to severe, and it may lead to dementia, in the
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A common class of drugs that doctors prescribe for a number of conditions — from bladder problems to Parkinson’s disease and depression — may increase a person’s risk of dementia, a large new study concludes. Some common drugs may increase dementia risk. New research by scientists from the University of Nottingham in the United Kingdom
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Researchers have found that nilvadipine, a drug that doctors regularly use to treat hypertension, may help people with Alzheimer’s disease by increasing blood flow to the brain. New research suggests that a high blood pressure drug may slow down the progression of Alzheimer’s disease. Alzheimer’s disease is the most common form of dementia. This progressive
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In this Spotlight, we introduce the glymphatic system: the brain’s dedicated waste clearance system. Now implicated in various conditions, it is high time that we became acquainted. Astroglia (illustrated above) play a pivotal role in the brain’s trash collection service. Many of us are relatively familiar with the lymphatic system; it performs a number of
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A large study concludes that atrial fibrillation does, indeed, raise the risk of dementia even in people who did not have a stroke and that anticoagulants may reduce this risk. An irregular heartbeat may be a sign of A-fib, which may, in turn, raise dementia risk. Atrial fibrillation (A-fib) is a condition in which the
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Researchers reveal a marker and new testing tool of frontotemporal dementia that may help distinguish this condition from Alzheimer’s disease. ‘Moral emotions’ are ones that prompt us to do good and contribute to pro-social behavior and cooperation. Frontotemporal dementia (FTD) is a less common form of dementia than Alzheimer’s. Sometimes called Pick’s disease or frontal
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New research in mice uncovers a previously unknown “pathway toward healthy aging.” A circulating protein from the blood of young mice led to health improvements and visible signs of rejuvenation when researchers gave it to aging mice. Scientists have found an enzyme that might have antiaging properties in humans as it does in mice. As
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Older adults with insufficient vitamin K are likely to be at higher risk for mobility disability, according to new research. New research shows that low levels of vitamin K may restrict mobility in older adults. Dietary sources of vitamin K include kale, spinach, broccoli, and other leafy greens. Some dairy foods also contain vitamin K.
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For many years, specialists believed that people who studied more and kept their brains more active had lower dementia risk. Some recent studies have contradicted this idea. So how is education linked to the evolution of Alzheimer’s disease, if at all? Another study suggests that there is no link between a person’s level of education
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Millions of people die prematurely each year due to noncommunicable diseases, some of the most common of which are cardiovascular diseases. New research from Harvard suggests that three tried and tested interventions could prevent many of those deaths if implemented through global policies. Three global interventions could prevent millions of deaths over the next couple
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There are two major stumbling blocks to developing effective drugs for Alzheimer’s, Parkinson’s, and other diseases that destroy the brain. The first is overcoming the blood-brain barrier, and the second is delivering the drug to a precise location and ensuring that it does not spread to the rest of the brain. New research finds a
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Many factors can cause eyebrow hair loss, including hormonal imbalances, diet, and some skin conditions. Determining the cause of eyebrow hair loss can help a person find the best treatment. Eyebrow hair loss, the medical name for which is eyebrow hypotrichosis, or eyebrow madarosis, can cause a person to notice thinning hair or missing patches
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A large new study has found a link between taking various kinds of blood pressure-lowering drugs and a lower risk of dementia among older adults, adding to the discussion around the link between cognitive decline and high blood pressure. People who take blood pressure-lowering medication may have a lower risk of dementia. Dementia is an
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Targeting the gut microbiome — the communities of bacteria and other microorganisms that inhabit the gastrointestinal tract — could be a way to treat a range of age-related conditions. Scientists made this conclusion after investigating the effect of transplanting fecal samples from young to aged mice. Jump-starting the gut bacteria may help people age more
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Clinical trials are underway to test whether rapamycin, a drug that has served as an immune suppressor for decades, could also treat cancer and neurodegeneration. Scientists are also interested in exploring its anti-aging properties. Scientists may have found anti-aging and neuroprotective benefits in an existing immunosuppressant drug. Rapamycin gets its name from Rapa Nui, the
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According to recent research in vitro and in mice, viruses that come into contact with biological fluids acquire a protein coating that renders them more infectious. Moreover, it seems that some viruses that ‘change identity’ in this way may promote neurodegenerative conditions, such as Alzheimer’s. Research shows that viruses can acquire a protein ‘coating’ that
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As people get older, their hair may start to lose volume and thickness. In some cases, thinning hair is linked with diet, nutrient deficiencies, or hereditary hair loss. In most cases, thinning hair is not linked with overall health concerns. However, it can affect people’s mental health and self-esteem. People can try several treatments and
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Currently, diagnosis of Parkinson’s disease relies on a neurologist’s professional opinion. Researchers behind a new study believe that an EEG may be a more effective alternative. New research suggests that an EEG test could help diagnose Parkinson’s disease. Parkinson’s disease affects more than 10 million people worldwide, according to the Parkinson’s Foundation, but no scan
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